Lopinavir/Ritonavir Solution

Pronunciation: loe-PIN-a-vir/rit-OH-na-vir
Generic Name: Lopinavir/Ritonavir
Brand Name: Kaletra

Lopinavir/Ritonavir Solution is used for:

Treating HIV infection. It is used along with other medicines for HIV.

Lopinavir/Ritonavir Solution is a combination of 2 HIV protease inhibitors. It works by stopping the HIV virus from multiplying.

Do NOT use Lopinavir/Ritonavir Solution if:

• you are allergic to any ingredient in Lopinavir/Ritonavir Solution


• you have a certain type of irregular heartbeat (congenital long QT syndrome) or low blood potassium levels


• you are taking alfuzosin, astemizole, certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), cisapride, conivaptan, disulfiram, eletriptan, an ergot derivative (eg, ergotamine, methylergonovine), meperidine, metronidazole, oral midazolam, pimozide, rifampin, salmeterol, St. John's wort, terfenadine, tipranavir, or triazolam


• you are taking sildenafil to treat pulmonary arterial hypertension (PAH)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lopinavir/Ritonavir Solution:

Some medical conditions may interact with Lopinavir/Ritonavir Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have hepatitis, other liver problems, or abnormal liver function tests


• if you have high cholesterol or triglyceride levels, or hemophilia or another bleeding disorder


• if you have a history of kidney problems, pancreas problems (eg, pancreatitis), diabetes or high blood sugar (hyperglycemia), or low potassium or magnesium blood levels


• if you have a history of alcohol abuse


• if you have a history of heart problems (eg, heart failure, conduction abnormalities), heart blood vessel problems, irregular heartbeat (eg, QT prolongation), or if you have a family member with a history of irregular heartbeat


• if you take another HIV protease inhibitor (eg, atazanavir, tipranavir)

Some MEDICINES MAY INTERACT with Lopinavir/Ritonavir Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Astemizole, cisapride, meperidine, pimozide, salmeterol, or terfenadine because serious side effects, such as seizures, blood problems, or heart problems (eg, irregular heartbeat), may occur


• Midazolam or triazolam because serious side effects, such as prolonged sedation or breathing problems, may occur


• Sildenafil (when used to treat PAH) because serious side effects, such as low blood pressure, prolonged erection, or vision changes, may occur


• Ergot derivatives (eg, ergotamine, methylergonovine) because serious blood flow problems may occur


• Rifampin, St. John's wort, or tipranavir because they may decrease Lopinavir/Ritonavir Solution's effectiveness


• Alfuzosin, conivaptan, eletriptan, or certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin) because the risk of their side effects may be increased by Lopinavir/Ritonavir Solution


• Disulfiram or metronidazole because severe nausea and vomiting may occur


• Many prescription and nonprescription medicines (eg, used for infections, HIV, inflammation, allergic reactions, allergies, asthma or other breathing problems, pain, birth control, blood thinning, cancer, enlarged prostate, gout, irregular heartbeat, other heart problems, high blood pressure, high cholesterol, immune suppression, erectile dysfunction, PAH, seizures, sleep disorders, smoking cessation, depression, other mood or mental problems), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo) may interact with Lopinavir/Ritonavir Solution, increasing the risk of side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lopinavir/Ritonavir Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lopinavir/Ritonavir Solution:

Use Lopinavir/Ritonavir Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Lopinavir/Ritonavir Solution comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Lopinavir/Ritonavir Solution refilled.


• Take Lopinavir/Ritonavir Solution by mouth with food.


• Use the dosing cup that comes with Lopinavir/Ritonavir Solution to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose.


• Lopinavir/Ritonavir Solution must be taken with other HIV medicines to be effective.


• If you are also taking didanosine, take it at least 1 hour before or 2 hours after you take Lopinavir/Ritonavir Solution.


• Taking Lopinavir/Ritonavir Solution at the same time each day will help you remember to take it.


• Continue to take Lopinavir/Ritonavir Solution even if you feel well. Do not miss any doses. Do not stop taking Lopinavir/Ritonavir Solution without checking with your doctor.


• If you miss a dose of Lopinavir/Ritonavir Solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lopinavir/Ritonavir Solution.

Important safety information:

• Lopinavir/Ritonavir Solution may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (eg, fever, sore throat, weakness, cough, shortness of breath) after you start Lopinavir/Ritonavir Solution.


• Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking Lopinavir/Ritonavir Solution. The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor.


• If the patient is a child, tell the child's doctor if his or her weight changes. The dose of Lopinavir/Ritonavir Solution may need to be changed.


• When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Lopinavir/Ritonavir Solution, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.


• Lopinavir/Ritonavir Solution is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.


• Lopinavir/Ritonavir Solution does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.


• Hormonal birth control (eg, birth control pills) may not work as well while you are taking Lopinavir/Ritonavir Solution. To prevent pregnancy, use an extra form of birth control (eg, condoms).


• Hemophilia patients - Report all bleeding episodes to your doctor.


• Lopinavir/Ritonavir Solution may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.


• Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Lab tests, including cholesterol and triglyceride levels, viral load, and liver function, may be performed while you use Lopinavir/Ritonavir Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Caution is advised when using Lopinavir/Ritonavir Solution in CHILDREN; they may be more sensitive to its effects, especially skin rash.


• Caution is advised when using Lopinavir/Ritonavir Solution in BABIES; they may be more sensitive to its effects, especially drowsiness and breathing problems.


• Lopinavir/Ritonavir Solution has alcohol and propylene glycol in it. Do not use it in PREMATURE NEWBORNS immediately after birth or in newborns younger than 14 days, unless your doctor has directed you otherwise. It may cause serious and possibly fatal side effects, such as heart problems (eg, heart muscle problems, slow or irregular heartbeat), high blood lactic acid levels, severe kidney problems, and severe drowsiness or breathing problems. Discuss any questions or concerns with your doctor.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Lopinavir/Ritonavir Solution while you are pregnant. It is not known if Lopinavir/Ritonavir Solution is found in breast milk. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Lopinavir/Ritonavir Solution to the baby.

Possible side effects of Lopinavir/Ritonavir Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; mild stomach pain or upset; nausea; tiredness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dizziness or light-headedness; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; loss of consciousness; red, swollen, blistered, or peeling skin; severe or persistent nausea, vomiting, or stomach pain; symptoms of high blood sugar (eg, confusion; flushed face; fruit-like breath odor; increased thirst, hunger, or urination; unusual drowsiness); symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools, loss of appetite, unusual fatigue); unusual bleeding or bruising.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Lopinavir/Ritonavir side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Lopinavir/Ritonavir Solution:

Store Lopinavir/Ritonavir Solution in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. If stored in the refrigerator, Lopinavir/Ritonavir Solution may be used until the expiration date printed on the label. Lopinavir/Ritonavir Solution may also be stored at room temperature up to 77 degrees F (25 degrees C). If stored at room temperature, throw away any medicine that is left after 2 months. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lopinavir/Ritonavir Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Lopinavir/Ritonavir Solution, please talk with your doctor, pharmacist, or other health care provider.


• Lopinavir/Ritonavir Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Lopinavir/Ritonavir Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Lopinavir/Ritonavir resources

• Lopinavir/Ritonavir Side Effects (in more detail)
• Lopinavir/Ritonavir Use in Pregnancy & Breastfeeding
• Lopinavir/Ritonavir Drug Interactions
• Lopinavir/Ritonavir Support Group
• 3 Reviews for Lopinavir/Ritonavir - Add your own review/rating

Compare Lopinavir/Ritonavir with other medications

• HIV Infection
• Nonoccupational Exposure

Yohimbine

Pronunciation: yoh-HIM-bean
Generic Name: Yohimbine
Brand Name: Examples include Aphrodyne and Yocon

Yohimbine is used for:

Dilating the pupils of the eye or treating erectile dysfunction due to diabetes, blood vessel problems, or psychological reasons. It may also be used for other conditions as determined by your doctor.

Yohimbine is an alpha-blocker. It works by increasing certain chemicals in the body, which dilate the pupils of the eye. It also dilates blood vessels and increases blood flow in the penis, which helps to improve erectile function.

Do NOT use Yohimbine if:

• you are allergic to any ingredient in Yohimbine


• if you are pregnant, planning to become pregnant, or are breast-feeding


• you have heart problems, kidney problems, ulcers of the stomach or intestines, or a history of mental or mood disorders


• you are taking medicines for mental or mood problems (eg, antidepressants, tranquilizers)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Yohimbine:

Some medical conditions may interact with Yohimbine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of heart problems, kidney problems, high blood pressure, angina (chest pain), stomach or intestinal ulcers, or liver disease

Some MEDICINES MAY INTERACT with Yohimbine. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Medicines for mood or mental problems (eg, antidepressants, tranquilizers) because side effects may be increased by Yohimbine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Yohimbine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Yohimbine:

Use Yohimbine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Yohimbine may be taken with or without food.


• It may take several weeks for Yohimbine to work.


• Do not exceed the recommended dose or take Yohimbine for more than 10 weeks without checking with your doctor.


• If you miss a dose of Yohimbine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Yohimbine.

Important safety information:

• Yohimbine may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Yohimbine. Using Yohimbine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Use Yohimbine with extreme caution in the ELDERLY because they may be more sensitive to its effects.


• Yohimbine is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Yohimbine is generally not recommended for use in women. Do not use Yohimbine if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. It is unknown if Yohimbine is excreted in breast milk. Do not breast-feed while taking Yohimbine.

Possible side effects of Yohimbine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; flushing; headache; nausea; nervousness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; decreased or painful urination; fast heartbeat; hallucinations; irritability; panic attacks; restlessness; severe headache; sweating; tremors; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Yohimbine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dizziness; excitation; fatigue; irritability; nervousness; paralysis; seizures; severe stomach upset; weakness.

Proper storage of Yohimbine:

Store Yohimbine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Yohimbine out of the reach of children and away from pets.

General information:

• If you have any questions about Yohimbine, please talk with your doctor, pharmacist, or other health care provider.


• Yohimbine is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Yohimbine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Yohimbine resources

• Yohimbine Side Effects (in more detail)
• Yohimbine Use in Pregnancy & Breastfeeding
• Drug Images
• Yohimbine Drug Interactions
• Yohimbine Support Group
• 2 Reviews for Yohimbine - Add your own review/rating

• yohimbine Advanced Consumer (Micromedex) - Includes Dosage Information


• yohimbine Concise Consumer Information (Cerner Multum)


• Yohimbe Natural MedFacts for Professionals (Wolters Kluwer)


• Yohimbe Natural MedFacts for Consumers (Wolters Kluwer)

Compare Yohimbine with other medications

• Erectile Dysfunction
• Sexual Dysfunction, SSRI Induced

minoxidil topical

Generic Name: minoxidil topical (mi NOX i dill)

Brand names: Rogaine, Rogaine Extra Strength, Ronoxidil, Rogaine Women's, Rogaine Men's Extra Strength

What is minoxidil topical?

The exact way that minoxidil topical works is not known.

Minoxidil topical is used to treat male pattern baldness.

Minoxidil topical may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about minoxidil topical?

Do not use minoxidil topical if the skin on your scalp is damaged, irritated, or sunburned. This may allow more of the medication to be absorbed by your body, which could be dangerous.

Do not use this medication on any part of your body other than your scalp. Application to other body parts can be dangerous.

Do not use other topical products on your scalp during treatment with minoxidil topical, unless otherwise directed by your doctor.

What should I discuss with my healthcare provider before using minoxidil topical?

Do not use minoxidil topical if the skin on your scalp is damaged, irritated, or sunburned. This may allow more of the medication to be absorbed by your body, which could be dangerous.

Before using minoxidil topical tell your doctor if you have heart disease. Minoxidil absorbed by the body can affect the heart.

Minoxidil topical is in the FDA pregnancy category C. This means that it is not known whether minoxidil topical will be harmful to an unborn to baby. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. Minoxidil may affect a nursing baby. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.

How should I use minoxidil topical?

Use minoxidil topical exactly as directed by your doctor or as directed in the package labeling. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Dry your hair and scalp before applying minoxidil topical.

Apply the prescribed amount, usually 1 mL, to the affected areas of the scalp. Minoxidil topical is usually applied twice daily, in the morning and at night.

Wash your hands after applying minoxidil topical.

Avoid getting this medication in the eyes, nose, or mouth. If this occurs, rinse the area with water.

Do not use minoxidil topical if the skin on your scalp is damaged, irritated, or sunburned. This may allow more of the medication to be absorbed by your body, which could be dangerous. Do not use more than 2 mL of minoxidil topical in one day. More medication will not increase or hasten hair growth but it may cause dangerous side effects.

Do not use this medication on any part of your body other than your scalp. Application to other body parts can be dangerous.

It may take 4 months or more before new hair growth is seen. New hair is usually soft, colorless, and barely visible. With further treatment, the hair will become similar in color and thickness to existing hair.

If no hair growth is seen after 4 months of treatment, discontinuation of minoxidil topical should be considered.

If treatment is discontinued, new hair growth will usually be shed within a few months.

Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and use only the next regularly scheduled dose. Do not use a double dose of this medication.

What happens if I overdose?

An overdose of minoxidil is not likely to occur.

If an unusually large dose is applied, or if the medication is ingested, seek emergency medical attention.

Symptoms of a minoxidil topical overdose are not known but may include very low blood pressure (fainting, dizziness, confusion); an irregular or fast heart rate; headache; and flushing (redness, warmth) of the skin.

What should I avoid while using minoxidil topical?

Do not use this medication on any part of your body other than your scalp. Application to other body parts can be dangerous.

Do not use other topical products on your scalp during treatment with minoxidil topical, unless otherwise directed by your doctor.

Minoxidil topical side effects

If you experience any of the following serious side effects, stop using minoxidil topical and seek emergency medical attention:

• 
  

  an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

  
  


• 
  

  chest pain;

  
  


• 
  

  irregular or very fast heartbeats;

  
  


• 
  

  dizziness or lightheadedness; or

  
  


• 
  

  fainting.

  
  

Continue to use minoxidil topical and talk to your doctor when it is convenient if you experience

• 
  

  itching, redness, dryness, or flaking of the scalp; or

  
  


• 
  

  a headache.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Minoxidil topical Dosing Information

Usual Adult Dose for Alopecia:

Solution:
Apply 1 mL topically to the affected area(s) of the scalp twice a day. The dose should not exceed 2 mL per day.

Foam:
Apply half a capful topically to the affected area(s) of the scalp twice a day.

What other drugs will affect minoxidil topical?

Do not use other topical products on your scalp during treatment with minoxidil topical, unless otherwise directed by your doctor.

Drugs other than those listed here may also interact with minoxidil topical or affect your condition. Talk to your doctor and pharmacist before using any prescription or over-the-counter medicines, including herbal products.

More minoxidil topical resources

• Minoxidil topical Use in Pregnancy & Breastfeeding
• Minoxidil topical Drug Interactions
• Minoxidil topical Support Group
• 7 Reviews for Minoxidil - Add your own review/rating

• Rogaine Topical Advanced Consumer (Micromedex) - Includes Dosage Information


• Rogaine Foam (For Men) MedFacts Consumer Leaflet (Wolters Kluwer)


• Rogaine Consumer Overview

Compare minoxidil topical with other medications

• Alopecia

Where can I get more information?

• Your pharmacist has additional information about minoxidil topical written for health professionals that you may read.

ISTA Pharmaceuticals, Inc.

Address ISTA Pharmaceuticals, Inc., 15295 Alton Parkway Irvine, CA 92618 Contact Details Phone: (949) 788-6000 Website: http://www.istavision.com/ Careers: http://search6.smartsearchonline.com...

tigecycline

Generic Name: tigecycline (tye ge SYE kleen)

Brand Names: Tygacil

What is tigecycline?

Tigecycline is an antibiotic that fights bacteria in the body.

Tigecycline is used to treat many different bacterial infections of the skin or the digestive system, as well as pneumonia.

Tigecycline may also be used for purposes not listed in this medication guide.

What is the most important information I should know about tigecycline?

Do not use this medicine if you are pregnant. It could harm the unborn baby or cause permanent tooth discoloration later in life.

Tigecycline can make birth control pills less effective. Ask your doctor about using a non hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using tigecycline.

You should not use this medication if you are allergic to tigecycline. Children should not use tigecycline. Tigecycline can cause permanent yellowing or graying of the teeth in children younger than 8 years old.

Before using tigecycline, tell your doctor if you are allergic to a tetracycline antibiotic such as demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap). Also tell your doctor if you have liver disease or if you are using a blood thinner such as warfarin (Coumadin, Jantoven).

You may be shown how to use an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection, and how to properly mix and store the medication.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

Avoid exposure to sunlight or tanning beds. Tigecycline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What should I discuss with my healthcare provider before using tigecycline?

You should not use this medication if you are allergic to tigecycline.

To make sure you can safely take tigecycline, tell your doctor if you have any of these other conditions:

• 
  

  liver disease;

  
  


• 
  

  if you are using a blood thinner such as warfarin (Coumadin, Jantoven); or

  
  


• 
  

  if you are allergic to a tetracycline antibiotic such as demeclocycline (Declomycin), doxycycline (Doryx, Oracea, Periostat, Vibramycin), minocycline (Dynacin, Minocin, Solodyn), or tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap).

  
  

Do not use this medicine if you are pregnant. It could harm the unborn baby or cause permanent tooth discoloration later in life. Tell your doctor right away if you become pregnant during treatment.

Tigecycline can make birth control pills less effective. Ask your doctor about using a non hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using tigecycline.

It is not known whether tigecycline passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Children should not use tigecycline. Tigecycline can cause permanent yellowing or graying of the teeth in children younger than 8 years old.

How should I use tigecycline?

Tigecycline is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Tigecycline must be given slowly, and the IV infusion can take up to 60 minutes to complete.

Tigecycline is a powder medicine that must be mixed with a liquid (diluent) in an IV bag before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication.

Prepare your dose only when you are ready to give yourself an injection. After mixing, the liquid should appear as a yellow or orange color. Do not use the medication if it has changed to green or black, or if it has any particles in it. Call your doctor for a new prescription.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Tigecycline will not treat a viral infection such as the common cold or flu.

Store unmixed powder at room temperature away from moisture and heat.

Mixed medicine must be used within 24 hours if you keep it at room temperature.

Tigecycline mixed in an IV bag with sodium chloride or dextrose solution may be stored in a refrigerator and used within 48 hours.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using tigecycline?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop using tigecycline and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Avoid exposure to sunlight or tanning beds. Tigecycline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Tigecycline side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using tigecycline and call your doctor at once if you have a serious side effect such as:

• 
  

  diarrhea that is watery or bloody;

  
  


• 
  

  severe headache, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;

  
  


• 
  

  nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

  
  


• 
  

  severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate.

  
  

Less serious side effects may include:

• 
  

  dizziness, sleep problems (insomnia);

  
  


• 
  

  headache; or

  
  


• 
  

  vaginal itching or discharge.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Tigecycline Dosing Information

Usual Adult Dose for Intraabdominal Infection:

100 mg IV initial dose, followed by 50 mg IV every 12 hours
Duration: 5 to 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Skin or Soft Tissue Infection:

100 mg IV initial dose, followed by 50 mg IV every 12 hours
Duration: 5 to 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Skin and Structure Infection:

100 mg IV initial dose, followed by 50 mg IV every 12 hours
Duration: 5 to 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Pneumonia:

Community acquired: 100 mg IV initial dose, followed by 50 mg IV every 12 hours
Duration: 7 to 14 days, depending on the nature and severity of the infection

What other drugs will affect tigecycline?

Do not give any of the following drugs through the same IV line used to give your tigecycline injection:

• 
  

  amphotericin (Amphocin, Fungizone);

  
  


• 
  

  amphotericin B lipid complex (Abelcet);

  
  


• 
  

  diazepam (Valium); or

  
  


• 
  

  esomeprazole (Nexium I.V.).

  
  

This list is not complete and other drugs may interact with tigecycline. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More tigecycline resources

• Tigecycline Side Effects (in more detail)
• Tigecycline Dosage
• Tigecycline Use in Pregnancy & Breastfeeding
• Tigecycline Drug Interactions
• Tigecycline Support Group
• 0 Reviews for Tigecycline - Add your own review/rating

• tigecycline Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information


• Tigecycline Professional Patient Advice (Wolters Kluwer)


• Tigecycline MedFacts Consumer Leaflet (Wolters Kluwer)


• Tigecycline Monograph (AHFS DI)


• Tygacil Prescribing Information (FDA)


• Tygacil Consumer Overview

Compare tigecycline with other medications

• Intraabdominal Infection
• Pneumonia
• Skin and Structure Infection
• Skin Infection

Where can I get more information?

• Your pharmacist can provide more information about tigecycline.

See also: tigecycline side effects (in more detail)

Mitrazol

Generic Name: miconazole topical (my CON a zole)

Brand Names: Aloe Vesta, Aloe Vesta 2 in 1 Antifungal, Baza, Cruex Prescription Strength, Desenex Prescription Strength, Fungoid, Fungoid Kit, Micatin, Micatin Cooling Action, Micatin Foot Powder, Micatin Foot Powder Deodorant, Micatin Jock Itch, Micatin Liquid Foot, Mitrazol, Monistat Derm, Ony-Clear, Zeasorb-AF

What is Mitrazol (miconazole topical)?

Miconazole topical is an antifungal medication. Miconazole topical prevents fungus from growing on your skin.

Miconazole topical is used to treat skin infections such as athlete's foot, jock itch, ringworm, tinea versicolor (a fungus that discolors the skin), and yeast infections.

Miconazole topical may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Mitrazol (miconazole topical)?

Use this medication for the full amount of time prescribed by your doctor or as recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed.

Do not use bandages or dressings that do not allow air to circulate to the affected area (occlusive dressings) unless otherwise directed by your doctor. Wear loose-fitting clothing (preferably cotton).

Avoid getting this medication in your eyes, nose, or mouth.

Who should not use Mitrazol (miconazole topical)?

Do not use miconazole topical if you have had an allergic reaction to it in the past.

It is not known whether miconazole topical will harm an unborn baby. Do not use miconazole topical without first talking to your doctor if you are pregnant. It is not known whether miconazole passes into breast milk. Do not use miconazole topical without first talking to your doctor if you are breast-feeding a baby.

How should I use Mitrazol (miconazole topical)?

Use miconazole topical exactly as directed by your doctor or follow the directions that accompany the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after using this medication.

Clean and dry the affected area. Apply the cream, lotion, spray, or powder once or twice daily as directed for 2 to 4 weeks.

Use this medication for the full amount of time prescribed by your doctor or as recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed.

If the infection does not clear up in 2 weeks (or 4 weeks for athlete's foot), or if it appears to get worse, see your doctor.

Do not use bandages or dressings that do not allow air circulation over the affected area (occlusive dressings) unless otherwise directed by your doctor. A light cotton-gauze dressing may be used to protect clothing.

Avoid getting this medication in your eyes, nose, or mouth. Store miconazole topical at room temperature away from moisture and heat.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the dose you missed and apply only the regular amount of miconazole topical. Do not use a double dose unless otherwise directed by your doctor.

What happens if I overdose?

An overdose of miconazole topical is unlikely to occur. If you do suspect that a much larger than normal dose has been used or that miconazole topical has been ingested, contact an emergency room or a poison control center.

What should I avoid while using Mitrazol (miconazole topical)?

Avoid wearing tight-fitting, synthetic clothing that doesn't allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed.

Mitrazol (miconazole topical) side effects

Serious side effects of miconazole topical use are not expected. Stop using miconazole topical and see your doctor if you experience unusual or severe blistering, itching, redness, peeling, dryness, or irritation of the skin.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Mitrazol (miconazole topical)?

Avoid using other topicals at the same time unless your doctor approves. Other skin medications may affect the absorption or effectiveness of miconazole topical.

More Mitrazol resources

• Mitrazol Side Effects (in more detail)
• Mitrazol Use in Pregnancy & Breastfeeding
• Mitrazol Drug Interactions
• Mitrazol Support Group
• 0 Reviews for Mitrazol - Add your own review/rating

• Mitrazol Topical Advanced Consumer (Micromedex) - Includes Dosage Information


• Cruex Prescription Strength Topical Advanced Consumer (Micromedex) - Includes Dosage Information


• Lotrimin AF Lotion MedFacts Consumer Leaflet (Wolters Kluwer)


• Micatin Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Monistat 3 Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Monistat 3 Prescribing Information (FDA)


• Monistat 7 Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Zeasorb-AF Gel MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Mitrazol with other medications

• Cutaneous Candidiasis
• Tinea Corporis
• Tinea Cruris
• Tinea Pedis
• Tinea Versicolor

Where can I get more information?

• Your pharmacist has additional information about miconazole topical written for health professionals that you may read.

See also: Mitrazol side effects (in more detail)

Dettol Antiseptic Wash

1. Name Of The Medicinal Product

Dettol Antiseptic Wash.

2. Qualitative And Quantitative Composition

Active Constituent	% w/v
Benzalkonium chloride	0.198

3. Pharmaceutical Form

Topical Spray.

4. Clinical Particulars

4.1 Therapeutic Indications

For the antiseptic cleansing of minor wounds such as cuts and skin grazes, insect bites and stings, small burns and scalds.

4.2 Posology And Method Of Administration

For adults and children: Spray onto the wound until it is visibly wet and clean, and any dirt and debris has been washed away. If necessary use a clean tissue or cotton wool to wipe up any excess liquid. Repeat as necessary.

4.3 Contraindications

None known.

4.4 Special Warnings And Precautions For Use

Label Warning: For external use only. Do not use around the eyes or ears, in the mouth or over large areas of the body. Do not inhale. In the case of accidental eye contact, the eye should be irrigated with copious amounts of cold water.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

None known.

4.6 Pregnancy And Lactation

Can be used.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

None known.

4.9 Overdose

Not applicable.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Benzalkonium chloride is a quaternary ammonium compound which has been used for many years as a surfactant and antiseptic/disinfectant. It is known to be bactericidal in low concentrations to a wide range of Gram-positive and Gram-negative bacteria.

5.2 Pharmacokinetic Properties

Quaternary ammonium compounds such as benzalkonium chloride are only absorbed to a very small extent through human skin.

5.3 Preclinical Safety Data

The low level of benzalkonium chloride in the product, coupled with its low level of absorption from intact and broken skin, make it unlikely that any significant systemic toxic effects would arise from its use. There is evidence that it can have an irritant effect on mucous membranes.

6. Pharmaceutical Particulars

6.1 List Of Excipients

The product contains the following excipients:

Propylene glycol

Sodium acid phosphate

Sodium phosphate

Mild pine perfume

Disodium edetate

Softened water

6.2 Incompatibilities

Benzalkonium chloride may be deactivated when used with soap or other surfactants.

6.3 Shelf Life

Two years at 30°C.

6.4 Special Precautions For Storage

Store below 30°C.

6.5 Nature And Contents Of Container

The liquid is contained in a natural HDPE container with a finger action spray pump for administration. The pump head is protected by a clear, polypropylene co-polymer overcap. The pack size is 100 ml.

6.6 Special Precautions For Disposal And Other Handling

Not applicable.

7. Marketing Authorisation Holder

Reckitt Benckiser (UK) Limited

103-105 Bath Road

Slough, SL1 3UH

United Kingdom

8. Marketing Authorisation Number(S)

PL 19718/0003

9. Date Of First Authorisation/Renewal Of The Authorisation

4 November 2002

10. Date Of Revision Of The Text

22/11/2010