Viibryd

Pronunciation: vil-AZ-oh-done
Generic Name: Vilazodone
Brand Name: Viibryd

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Viibryd outweigh the risks.

Families and caregivers must closely watch patients who take Viibryd. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.

Viibryd is used for:

Treating depression. It may also be used for other conditions as determined by your doctor.

Viibryd is an antidepressant. It is thought to work by increasing the activity of one of the brain chemicals (serotonin), which helps elevate mood.

Do NOT use Viibryd if:

• you are allergic to any ingredient in Viibryd or to nefazodone


• you are taking rasagiline or tryptophan


• you are taking or have taken linezolid, methylene blue, a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), or St. John's wort within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Video: Treatment for Depression

Treatments for depression are getting better everyday and there are things you can start doing right away.

Before using Viibryd:

Some medical conditions may interact with Viibryd. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have low blood volume, low blood pressure, or low blood sodium levels; you are dehydrated; or you are on a low-salt (sodium) diet


• if you or a family member has a history of bipolar disorder (manic-depression) or other mental or mood problems (eg, depression), suicidal thoughts or attempts, alcohol or substance abuse, or if you drink alcohol


• if you have a history of liver problems, kidney problems, bleeding problems, or seizures

Some MEDICINES MAY INTERACT with Viibryd. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, intranasal ketorolac), or salicylates (eg, aspirin) because the risk of bleeding may be increased


• Antipsychotics (eg, olanzapine, haloperidol), buspirone, fenfluramine or its derivatives (eg, dexfenfluramine), linezolid, MAOIs, (eg, phenelzine), methylene blue, metoclopramide, narcotic (opioid) pain medicines (eg, morphine), phenothiazines (eg, thioridazine), rasagiline, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), selegiline, serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine, venlafaxine), sibutramine, St. John's wort, tramadol, "triptans" (eg, sumatriptan), or tryptophan because severe side effects, such as a reaction that may include fever, rigid muscles, blood pressure changes, mental changes, confusion, irritability, agitation, delirium, or coma, may occur


• Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood sodium levels may be increased


• Azole antifungals (eg, itraconazole, ketoconazole), HIV protease inhibitors (eg, indinavir, ritonavir), macrolide antibiotics (eg, clarithromycin, erythromycin), nefazodone, or telithromycin because the risk of Viibryd's side effects may be increased


• Cyproheptadine because it may decrease Viibryd's effectiveness


• Lithium because the risk of its side effects may be increased by Viibryd

This may not be a complete list of all interactions that may occur. Ask your health care provider if Viibryd may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Viibryd:

Use Viibryd as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Viibryd comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Viibryd refilled.


• Take Viibryd by mouth with food.


• When starting Viibryd, your doctor may slowly increase your dose to avoid side effects. Discuss any questions or concerns with your doctor.


• It may take 1 to 4 weeks for Viibryd to work. Do not stop taking Viibryd without checking with your doctor.


• Do not suddenly stop taking Viibryd. You may have an increased risk of side effects. If you need to stop Viibryd, your doctor will gradually lower your dose.


• If you miss a dose of Viibryd, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Viibryd.

Important safety information:

• Viibryd may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Viibryd with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol while you are using Viibryd.


• Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Viibryd; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Be sure to keep all doctor appointments while you are taking Viibryd.


• Children, teenagers, and young adults who take Viibryd may be at increased risk of suicidal thoughts or actions. Watch all patients who take Viibryd closely. Contact the doctor at once if new, worsened, or sudden symptoms, such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior, occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.


• Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Viibryd. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.


• Serotonin syndrome is a possibly fatal syndrome that can be caused by Viibryd. Your risk may be greater if you take Viibryd with certain other medicines (eg, "triptans," MAOIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.


• Tell your doctor or dentist that you take Viibryd before you receive any medical or dental care, emergency care, or surgery.


• Use Viibryd with caution in the ELDERLY; they may be more sensitive to its effects, especially low blood sodium levels.


• Viibryd should not be used in CHILDREN or TEENAGERS; safety and effectiveness in children and teenagers have not been confirmed. Children and teenagers may also be more sensitive to its effects, especially the increased risk of suicidal thoughts or actions.


• PREGNANCY and BREAST-FEEDING: Viibryd may cause harm to the fetus if taken during the third trimester of pregnancy. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Viibryd while you are pregnant. Viibryd is found in breast milk. If you are or will be breast-feeding while you take Viibryd, check with your doctor. Discuss any possible risks to your baby.

Do not suddenly stop taking Viibryd. If you do, you may have WITHDRAWAL symptoms. These may include feeling unwell or unhappy, anxious or irritable, dizzy, confused, or sluggish. You may also have nausea, unusual skin sensations, mood swings, headache, trouble sleeping, or sweating. If you need to stop Viibryd, your doctor will lower your dose over time.

Possible side effects of Viibryd:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Decreased sexual desire or ability; diarrhea; dizziness; drowsiness; dry mouth; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); behavior changes; black, tarry, or bloody stools; bloody or dark urine; blurred vision; decreased coordination; fainting; hallucinations; irregular heartbeat; new or worsening agitation, anxiety, depression, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, restlessness, trouble sleeping, or inability to sit still; seizures; severe or persistent dizziness; suicidal thoughts or actions; symptoms of low blood sodium levels (eg, confusion, severe or persistent headache, trouble concentrating, memory problems, weakness, unsteadiness, sluggishness); tremor; unusual bruising or bleeding; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Viibryd side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; confusion; disorientation; excessive sweating; fast or irregular heartbeat; fever; hallucinations; loss of consciousness or coma; nausea, vomiting, or diarrhea; restlessness; tiredness or weakness; tremor.

Proper storage of Viibryd:

Store Viibryd at 77 degrees F (25 degrees C) in a tight, light-resistant container. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Viibryd out of the reach of children and away from pets.

General information:

• If you have any questions about Viibryd, please talk with your doctor, pharmacist, or other health care provider.


• Viibryd is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is summary only. It does not contain all information about Viibryd. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Viibryd resources

• Viibryd Side Effects (in more detail)
• Viibryd Use in Pregnancy & Breastfeeding
• Viibryd Drug Interactions
• Viibryd Support Group
• 81 Reviews for Viibryd - Add your own review/rating

• Viibryd Prescribing Information (FDA)


• Viibryd Advanced Consumer (Micromedex) - Includes Dosage Information


• Viibryd Consumer Overview

Compare Viibryd with other medications

• Depression

Excedrin Tension Headache Caplet

Generic Name: acetaminophen and caffeine (a SEET a MIN oh fen and KAF een)

Brand Names: Excedrin Quick Tab Peppermint, Excedrin Quick Tab Spearmint, Excedrin Tension Headache, Excedrin Tension Headache Caplet, Excedrin Tension Headache Express Gels, Excedrin Tension Headache Geltab, Valorin Extra

What is Excedrin Tension Headache Caplet (acetaminophen and caffeine)?

Acetaminophen is a pain reliever and a fever reducer.

Caffeine is used in this product to increase the pain relieving effects of acetaminophen.

The combination of acetaminophen and caffeine is used to treat pain from conditions such as headache, muscle aches, menstrual cramps, arthritis, backache, toothaches, colds and fevers.

Acetaminophen and caffeine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Excedrin Tension Headache Caplet (acetaminophen and caffeine)?

Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

What should I discuss with my healthcare provider before taking Excedrin Tension Headache Caplet (acetaminophen and caffeine)?

Do not take this medication if you are allergic to acetaminophen (Tylenol) or caffeine. Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have kidney or liver disease, or a history of alcoholism.

It is not known whether this medicine will harm an unborn baby. Do not take acetaminophen and caffeine without medical advice if you are pregnant. Acetaminophen and caffeine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Excedrin Tension Headache Caplet (acetaminophen and caffeine)?

Use this medication exactly as directed on the label, or as prescribed by your doctor.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

One acetaminophen and caffeine pill contains 500 mg of acetaminophen. Know the amount of acetaminophen in the specific product you are taking.

The orally disintegrating tablet (Excedrin QuickTabs) should be placed directly on the tongue. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Call your doctor if your symptoms do not improve, especially if you still have a fever after 3 days of using this medication, or pain after 10 days of use. Stop taking acetaminophen and caffeine and call your doctor at any time if your symptoms get worse.

Acetaminophen may cause false urine glucose test results. Talk to your doctor if you have diabetes and you notice changes in glucose test results while taking acetaminophen and caffeine.

Store at room temperature away from heat and moisture.

What happens if I miss a dose?

Since acetaminophen and caffeine is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include loss of appetite, confusion, nausea, vomiting, diarrhea, sweating, fast or uneven heart rate, seizure (convulsions), pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

What should I avoid while taking Excedrin Tension Headache Caplet (acetaminophen and caffeine)?

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen. Avoid coffee, tea, cola, energy drinks or other sources of caffeine while taking this medication. They can add to the side effects of the caffeine in the medication.

Excedrin Tension Headache Caplet (acetaminophen and caffeine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using acetaminophen and caffeine and call your doctor at once if you have a serious side effect such as:

• 
  

  low fever with nausea, stomach pain, and loss of appetite;

  
  


• 
  

  dark urine, clay-colored stools; or

  
  


• 
  

  jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  sleep problems (insomnia); or

  
  


• 
  

  feeling nervous, irritable, or jittery.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Excedrin Tension Headache Caplet (acetaminophen and caffeine)?

There may be other drugs that can interact with acetaminophen and caffeine. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Excedrin Tension Headache Caplet resources

• Excedrin Tension Headache Caplet Side Effects (in more detail)
• Excedrin Tension Headache Caplet Use in Pregnancy & Breastfeeding
• Excedrin Tension Headache Caplet Drug Interactions
• Excedrin Tension Headache Caplet Support Group
• 2 Reviews for Excedrin Tension Headache Caplet - Add your own review/rating

Compare Excedrin Tension Headache Caplet with other medications

• Cold Symptoms
• Headache
• Osteoarthritis
• Pain
• Period Pain
• Sinusitis

Where can I get more information?

• Your pharmacist can provide more information about acetaminophen and caffeine.

See also: Excedrin Tension Headache Caplet side effects (in more detail)

hydrochlorothiazide and captopril

Generic Name: hydrochlorothiazide and captopril (hye droe klor oh THY a zide and KAP toe pril)

Brand Names: Capozide 25/15, Capozide 25/25, Capozide 50/15, Capozide 50/25

What is hydrochlorothiazide and captopril?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Captopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Captopril lowers blood pressure and also relieves symptoms of fluid retention.

The combination of hydrochlorothiazide and captopril is used to treat hypertension (high blood pressure).

Hydrochlorothiazide and captopril may also be used for purposes not listed in this medication guide.

What is the most important information I should know about hydrochlorothiazide and captopril?

You should not use this medication if you are allergic to hydrochlorothiazide or captopril, or if you have a history of asthma or allergies, or you are unable to urinate.

You should not use this medication if you are allergic to any other ACE inhibitor, such as benazepril (Lotensin), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

Before taking hydrochlorothiazide and captopril, tell your doctor if you have kidney disease (or are on dialysis), liver disease, glaucoma, congestive heart failure, gout, lupus, diabetes, or an allergy to sulfa drugs or penicillin.

Do not use hydrochlorothiazide and captopril if you are pregnant. It could harm the unborn baby.

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and captopril, unless your doctor has told you to.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and captopril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

What should I discuss with my healthcare provider before taking hydrochlorothiazide and captopril?

Do not use this medication if you are allergic to hydrochlorothiazide or captopril, or if you have:

• 
  

  a history of asthma or allergies; or

  
  


• 
  

  if you are unable to urinate.

  
  

You should not use this medication if you are allergic to any other ACE inhibitor, such as benazepril (Lotensin), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

To make sure you can safely take hydrochlorothiazide and captopril, tell your doctor if you have any of these other conditions:

• kidney disease (or if you are on dialysis);


• liver disease;


• 
  

  glaucoma;

  
  


• 
  

  congestive heart failure;

  
  


• 
  

  gout;

  
  


• 
  

  lupus;

  
  


• 
  

  diabetes; or

  
  


• 
  

  an allergy to sulfa drugs or penicillin

  
  

FDA pregnancy category D. Do not use hydrochlorothiazide and captopril if you are pregnant. It could harm the unborn baby. Stop using this medication and tell your doctor right away if you become pregnant. Use effective birth control while taking hydrochlorothiazide and captopril. Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take hydrochlorothiazide and captopril?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Take each dose with a full glass of water.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and captopril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated. Visit your doctor regularly.

Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using a thiazide diuretic.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture, heat, and light.

See also: Hydrochlorothiazide and captopril dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, weakness, dizziness, dry mouth, thirst, muscle pain or weakness, or feeling like you might pass out.

What should I avoid while taking hydrochlorothiazide and captopril?

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and captopril.

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and captopril, unless your doctor has told you to.

Hydrochlorothiazide and captopril side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  eye pain, vision problems;

  
  


• 
  

  high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling);

  
  


• 
  

  low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);

  
  


• 
  

  dry mouth, thirst, nausea, vomiting;

  
  


• 
  

  feeling weak, drowsy, restless, or light-headed;

  
  


• 
  

  a red, blistering, peeling skin rash;

  
  


• 
  

  jaundice (yellowing of the skin or eyes);

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  swelling, weight gain, feeling short of breath; or

  
  


• 
  

  fever, chills, body aches, flu symptoms.

  
  

Less serious side effects may include:

• 
  

  cough;

  
  


• 
  

  dizziness, headache, tired feeling;

  
  


• 
  

  blurred vision;

  
  


• 
  

  diarrhea, constipation, upset stomach; or

  
  


• 
  

  mild skin rash, increased sweating.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Hydrochlorothiazide and captopril Dosing Information

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 1 tablet of (captopril-hydrochlorothiazide 25 mg/15 mg) orally once a day, one hour before meals. Determine dosage by individual titration.
Maintenance dose: May use additional captopril or hydrochlorothiazide as individual components or change to an increased strength of the combination tablet. May give the combination tablet in divided doses up to 3 times a day. In general, daily doses of captopril should not exceed 150 mg and of hydrochlorothiazide should not exceed 50 mg.

Usual Adult Dose for Hypertension:

Initial dose: 1 tablet of (captopril-hydrochlorothiazide 25 mg/15 mg) orally once a day, one hour before meals. Determine dosage by individual titration.
Maintenance dose: May use additional captopril or hydrochlorothiazide as individual components or change to an increased strength of the combination tablet. May give the combination tablet in divided doses up to 3 times a day. In general, daily doses of captopril should not exceed 150 mg and of hydrochlorothiazide should not exceed 50 mg.

What other drugs will affect hydrochlorothiazide and captopril?

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to the side effects of hydrochlorothiazide and captopril. Tell your doctor if you regularly use any of these medicines, or any other blood pressure medications.

Tell your doctor about all other medicines you use, especially:

• 
  

  gold injections to treat arthritis;

  
  


• 
  

  other diuretics (water pills) or blood pressure medications;

  
  


• 
  

  lithium (Lithobid, Eskalith);

  
  


• 
  

  a blood thinner such as warfarin (Coumadin, Jantoven);

  
  


• 
  

  digoxin (Lanoxin);

  
  


• 
  

  nitroglycerin (Nitrolingual, Nitrostat, Nitro-Dur, and others);

  
  


• 
  

  cholestyramine (Prevalite, Questran) or colestipol (Colestid);

  
  


• 
  

  steroids (prednisone and others);

  
  


• 
  

  NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others; or

  
  


• 
  

  insulin or diabetes medicine taken by mouth.

  
  

This list is not complete and other drugs may interact with hydrochlorothiazide and captopril. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More hydrochlorothiazide and captopril resources

• Hydrochlorothiazide and captopril Side Effects (in more detail)
• Hydrochlorothiazide and captopril Dosage
• Hydrochlorothiazide and captopril Use in Pregnancy & Breastfeeding
• Drug Images
• Hydrochlorothiazide and captopril Drug Interactions
• Hydrochlorothiazide and captopril Support Group
• 0 Reviews for Hydrochlorothiazide and captopril - Add your own review/rating

Compare hydrochlorothiazide and captopril with other medications

• Heart Failure
• High Blood Pressure

Where can I get more information?

• Your pharmacist can provide more information about hydrochlorothiazide and captopril.

See also: hydrochlorothiazide and captopril side effects (in more detail)

Flumazenil

Pronunciation: FLOO-may-ze-nil
Generic Name: Flumazenil
Brand Name: Romazicon

Flumazenil may cause seizures, especially in patients who have been on benzodiazepines (eg, diazepam) for a long time or if a patient has taken too much of a benzodiazepine (overdose).

Flumazenil is used for:

Reversing drowsiness, sedation, and other effects caused by benzodiazepines.

Flumazenil is a benzodiazepine antagonist. It works by blocking receptors in the brain and central nervous system that benzodiazepines need to reach to be active, which helps reduce drowsiness and sedation.

Do NOT use Flumazenil if:

• you are allergic to any ingredient in Flumazenil or to benzodiazepines (eg, alprazolam)


• you have been given a benzodiazepine for control of a potentially life-threatening condition (eg, increased pressure in the head, seizures)


• you are experiencing side effects due to an overdose of a medicine used to treat depression

Contact your doctor or health care provider right away if any of these apply to you.

Video: Treatment for Depression

Treatments for depression are getting better everyday and there are things you can start doing right away.

Before using Flumazenil:

Some medical conditions may interact with Flumazenil. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine (especially benzodiazepines), herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of seizures, panic disorder, liver problems, alcohol or other substance abuse, or you have had a recent head injury

Some MEDICINES MAY INTERACT with Flumazenil. However, no specific interactions with Flumazenil are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Flumazenil may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Flumazenil:

Use Flumazenil as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Flumazenil is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Flumazenil at home, carefully follow the injection procedures taught to you by your health care provider.


• If Flumazenil contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.


• If Flumazenil accidentally spills on your skin, wash it off immediately with soap and water.


• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.


• If you miss a dose of Flumazenil, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Flumazenil.

Important safety information:

• Flumazenil may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Flumazenil. Using Flumazenil alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Avoid drinking alcohol or taking other medicines that cause drowsiness (eg, sedatives, tranquilizers) for at least 24 hours after receiving Flumazenil. Flumazenil will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.


• Although Flumazenil is given to reverse drowsiness, you may experience a return of drowsiness for up to 24 hours after Flumazenil is given. If you notice a return of drowsiness or experience shortness of breath, contact your doctor as soon as possible.


• Flumazenil is not recommended for use in CHILDREN younger than 1 year of age. Safety and effectiveness in this age group have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Flumazenil, discuss with your doctor the benefits and risks of using Flumazenil during pregnancy. It is unknown if Flumazenil is excreted in breast milk. If you are or will be breast-feeding while you are using Flumazenil, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Flumazenil:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal or blurred vision; abnormal skin sensations; changes in vision; clumsiness; dizziness; dry mouth; feeling of a whirling motion; flushing; general body discomfort; headache; hot flashes; increased sweating; nausea; nervousness; pain at the injection site; restlessness; sleeplessness; sweating; tiredness; tremors; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; change in behavior, mood, or emotions (eg, anxiety, depression); pounding in the chest; rapid deep breathing; seizures.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Flumazenil side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; anxiety; emotional or mood changes; increased sensitivity to pain or touch; seizures.

Proper storage of Flumazenil:

Flumazenil is usually handled and stored by a health care provider. If you are using Flumazenil at home, store Flumazenil as directed by your pharmacist or health care provider. Keep Flumazenil out of the reach of children and away from pets.

General information:

• If you have any questions about Flumazenil, please talk with your doctor, pharmacist, or other health care provider.


• Flumazenil is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Flumazenil. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Flumazenil resources

• Flumazenil Side Effects (in more detail)
• Flumazenil Use in Pregnancy & Breastfeeding
• Flumazenil Drug Interactions
• Flumazenil Support Group
• 0 Reviews for Flumazenil - Add your own review/rating

• Flumazenil Monograph (AHFS DI)


• Flumazenil Professional Patient Advice (Wolters Kluwer)


• flumazenil Concise Consumer Information (Cerner Multum)


• Romazicon Prescribing Information (FDA)

Compare Flumazenil with other medications

• Benzodiazepine Overdose
• Reversal of Sedation

Etopophos

Generic Name: etoposide phosphate (e TOE poe side FOS fate)

Brand Names: Etopophos

What is Etopophos (etoposide phosphate)?

Etoposide phosphate is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body.

Etoposide phosphate is used to treat cancer of the lung or testicles.

Etoposide phosphate may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Etopophos (etoposide phosphate)?

Do not receive etoposide phosphate if you are pregnant. It could harm the unborn baby.

Before receiving etoposide phosphate, tell your doctor if you have kidney disease or a weak immune system.

Etoposide phosphate can lower the blood cells that help your body fight infections. Avoid being near people who are sick or have infections. Avoid activities that may increase your risk of bleeding or injury. Tell your doctor at once if you develop signs of infection.

Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. Visit your doctor regularly.

Using etoposide phosphate may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.

What should I discuss with my health care provider before using Etopophos (etoposide phosphate)?

You should not use this medication if you are allergic to etoposide.

To make sure you can safely receive etoposide phosphate, tell your doctor if you have any of these other conditions:

• kidney disease; or


• 
  

  a weak immune system (from disease or from taking certain medicines).

  
  

FDA pregnancy category D. Do not use etoposide phosphate if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether etoposide phosphate passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are being treated with etoposide phosphate.

Using etoposide phosphate may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.

How is etoposide phosphate given?

Etoposide phosphate is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. The medicine is sometimes given slowly through an IV infusion, and can take up to 3-1/2 hours to complete.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when etoposide phosphate is injected.

Etoposide phosphate is usually given for 4 or 5 days in a row every 3 to 4 weeks. Follow your doctor's instructions.

Etoposide phosphate can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill.

Your blood may need to be tested often. Your cancer treatments may be delayed based on the results of these tests. Visit your doctor regularly.

Etoposide phosphate is used together with other cancer medications. Read the medication guide or patient instructions provided with each of your medications.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your etoposide phosphate injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving Etopophos (etoposide phosphate)?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Etopophos (etoposide phosphate) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  fever, chills, body aches, flu symptoms, sores in your mouth and throat;

  
  


• 
  

  easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

  
  


• 
  

  pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;

  
  


• 
  

  pain, burning, irritation, or skin changes where the injection was given;

  
  


• 
  

  feeling like you might pass out; or

  
  


• 
  

  severe nausea and vomiting.

  
  

Less serious side effects may include:

• 
  

  mild nausea, vomiting, stomach pain, loss of appetite;

  
  


• 
  

  constipation, diarrhea;

  
  


• 
  

  dizziness, feeling tired or weak;

  
  


• 
  

  temporary hair loss; or

  
  


• 
  

  mild skin rash.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Etopophos (etoposide phosphate)?

Before you receive etoposide phosphate, tell your doctor if you are using cyclosporine (Neoral, Sandimmune, Gengraf).

There may be other drugs that can interact with etoposide phosphate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Etopophos resources

• Etopophos Side Effects (in more detail)
• Etopophos Use in Pregnancy & Breastfeeding
• Etopophos Drug Interactions
• Etopophos Support Group
• 0 Reviews for Etopophos - Add your own review/rating

• Etopophos Prescribing Information (FDA)


• Etopophos Advanced Consumer (Micromedex) - Includes Dosage Information


• Etopophos MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Etopophos with other medications

• Cancer
• Hodgkin's Lymphoma
• Ovarian Cancer
• Small Cell Lung Cancer
• Testicular Cancer

Where can I get more information?

• Your doctor or pharmacist can provide more information about etoposide phosphate.

See also: Etopophos side effects (in more detail)

Victrelis

Generic Name: boceprevir (Oral route)

boe-SE-pre-vir

Commonly used brand name(s)

In the U.S.

• Victrelis

Available Dosage Forms:

• Capsule

Pharmacologic Class: Protease Inhibitor

Uses For Victrelis

Boceprevir is used in combination with injectable peginterferon alfa (Pegasys®, Pegintron®) and ribavirin (Copegus®, Rebetol®) to treat chronic hepatitis C infection. These medicines are used in patients with compensated liver disease (including cirrhosis), who have not been treated before or who have received other medicines but did not work well. Boceprevir is a direct-acting antiviral agent that treats hepatitis C infection.

This medicine is available only with your doctor's prescription.

Before Using Victrelis

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of boceprevir in the pediatric population. Safety and efficacy have not been established.

Geriatric

Although appropriate studies on the relationship of age to the effects of boceprevir have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have age-related liver problems, which may require caution in patients receiving boceprevir.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Alfuzosin


• Carbamazepine


• Cisapride


• Colchicine


• Dihydroergotamine


• Drospirenone


• Ergonovine


• Ergotamine


• Lovastatin


• Methylergonovine


• Midazolam


• Phenobarbital


• Phenytoin


• Pimozide


• Rifampin


• Sildenafil


• Simvastatin


• St John's Wort


• Tadalafil


• Triazolam

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alprazolam


• Amiodarone


• Bepridil


• Budesonide


• Dexamethasone


• Digoxin


• Efavirenz


• Ethinyl Estradiol


• Flecainide


• Fluticasone


• Itraconazole


• Posaconazole


• Propafenone


• Quinidine


• Rifabutin


• Ruxolitinib


• Salmeterol


• Sirolimus


• Sunitinib


• Vardenafil


• Voriconazole

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Ketoconazole

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood or bone marrow problems (e.g., anemia, neutropenia)—Use with caution. May make these conditions worse.

Proper Use of Victrelis

To help clear up your infection completely, boceprevir must be taken together with peginterferon alfa and ribavirin for the full time of treatment, even if you begin to feel better after a few days. Also, it is important to keep the amount of medicine in your body at a steady level. To help keep the amount constant, boceprevir must be used on a regular schedule.

Take this medicine with a meal or light snack.

Do not change or suddenly stop using this medicine without checking first with your doctor.

This medicine should come with a Medication Guide. Read and follow the information carefully. Ask your doctor if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (capsules):
  
  • For hepatitis C virus infection, in combination with peginterferon alfa and ribavirin:
    
    • Adults—800 milligrams (mg) (four 200-mg capsules) three times a day with food. Each dose should be taken 7 to 9 hours apart.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose or forget to use it, and it is less than 2 hours before your next regular dose, wait until then to take the medicine and skip the missed dose. If you miss a dose and it is more than 2 hours before your next regular dose, go ahead and take the missed dose and take the next regular dose as scheduled. If you have any questions about this, ask your pharmacist or doctor.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Victrelis

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine together with peginterferon alfa and ribavirin while you are pregnant can harm your unborn baby. These medicines may also cause birth defects if the father is using it when his sexual partner becomes pregnant. If a pregnancy occurs while you are using these medicines, tell your doctor right away.

To make sure you are not pregnant, your doctor may ask you to have a pregnancy test before you start using this medicine. You must have a negative pregnancy test before you will be allowed to use this medicine with ribavirin. Two forms of birth control must be used during treatment and for 6 months after treatment ends. You should test for pregnancy every month while you are using this medicine, and for 6 months after your treatment ends.

Birth control pills may not work while you are using this medicine. To keep from getting pregnant, use two other forms of birth control. Other forms of birth control include condoms, diaphragms, or contraceptive foams or jellies.

Do not use this medicine together with the following medicines: alfuzosin (Uroxatral®), cisapride (Propulsid®), drospirenone (Yasmin®, Yaz®), oral midazolam (Versed®), pimozide (Orap®), rifampin (Rifadin®, Rimactane®), sildenafil (Revatio®), St. John's wort, tadalafil (Adcirca®), triazolam (Halcion®), certain medicines to lower cholesterol (such as lovastatin, simvastatin, Mevacor®, or Zocor®), medicines to treat seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, or Tegretol®), or ergot medicines (such as dihydroergotamine, ergonovine, ergotamine, methylergonovine, DHE 45®, Ergomar®, Ergotrate®, or Methergine®). Using boceprevir with any of these medicines can cause very serious medical problems.

Check with your doctor right away if you have back, leg, or stomach pains; bleeding gums; chills; dark urine; difficulty with breathing; fever; general body swelling; headache; loss of appetite; nausea or vomiting; nosebleeds; pale skin; sore throat; unusual tiredness or weakness; or yellowing of the eyes or skin. These could be symptoms of a blood disorder called anemia.

Birth control pills may not work while you are using this medicine. To keep from getting pregnant, use two other forms of birth control. Other forms of birth control include condoms, diaphragms, or contraceptive foams or jellies.

Using this medicine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets in the blood, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

• If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.


• Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin.


• Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.


• Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.


• Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.


• Avoid contact sports or other situations where bruising or injury could occur.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

This medicine will not keep you from giving hepatitis C to other people. Follow your doctor's instructions about how to prevent the spread of this infection.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Victrelis Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Black, tarry stools


• chills


• cough


• difficult or labored breathing


• fever


• lower back or side pain


• painful or difficult urination


• pale skin


• shortness of breath


• sore throat


• tightness in the chest


• troubled breathing with exertion


• ulcers, sores, or white spots in the mouth


• unusual bleeding or bruising


• unusual tiredness or weakness


• wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Change in taste


• decreased appetite


• diarrhea


• difficulty with moving


• dizziness


• dry mouth


• dry skin


• hair loss or thinning of the hair


• irritability


• lack or loss of strength


• loss of taste


• muscle pain or stiffness


• nausea


• pain in the joints


• rash


• sleeplessness


• trouble sleeping


• unable to sleep


• vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

Azelex Cream

Pronunciation: aze-eh-LAY-ik ASS-id
Generic Name: Azelaic Acid
Brand Name: Azelex

Azelex Cream is used for:

Treating mild to moderate acne.

Azelex Cream is a topical antibacterial. Exactly how it works is unknown, but it may block production of proteins necessary for the bacteria to survive.

Do NOT use Azelex Cream if:

• you are allergic to any ingredient in Azelex Cream

Contact your doctor or health care provider right away if any of these apply to you.

Before using Azelex Cream:

Some medical conditions may interact with Azelex Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of asthma or cold sores

Some MEDICINES MAY INTERACT with Azelex Cream. Because little, if any, of Azelex Cream is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Azelex Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Azelex Cream:

Use Azelex Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Before using Azelex Cream, wash the affected area with warm water and soap, rinse, and pat dry. Cover the affected area with a thin film of medicine and gently rub in until medicine is evenly distributed. Allow the medicine to dry.


• Wash your hands immediately before and after using Azelex Cream.


• Do not cover the affected area with gauze or a bandage unless your doctor tells you to do so.


• Continue to use Azelex Cream for the full course of treatment even if your condition improves. Do not miss any doses.


• If you miss a dose of Azelex Cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Ask your health care provider any questions you may have about how to use Azelex Cream.

Important safety information:

• It may take several weeks for Azelex Cream to work. If your symptoms do not get better within 4 weeks or if they get worse, check with your doctor.


• Azelex Cream is for external use only. Avoid getting Azelex Cream in your vagina, eyes, nose, or mouth. If Azelex Cream does get into your eyes, wash your eyes immediately with plenty of water. If eye irritation continues, contact your doctor.


• If you use topical products too often, your condition may become worse.


• Azelex Cream may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.


• Talk with your doctor before you use any other medicines or cleansers on your skin.


• Azelex Cream should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Azelex Cream while you are pregnant. It is not known if Azelex Cream is found in breast milk. If you are or will be breast-feeding while you use Azelex Cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Azelex Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dryness; temporary burning, itching, redness, stinging, or tingling at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in skin color; peeling, irritation, or inflammation of skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Azelex side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Azelex Cream:

Store Azelex Cream at room temperature, between 59 and 86 degrees F (15 to 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Do not freeze. Keep Azelex Cream out of the reach of children and away from pets.

General information:

• If you have any questions about Azelex Cream, please talk with your doctor, pharmacist, or other health care provider.


• Azelex Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Azelex Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Azelex resources

• Azelex Side Effects (in more detail)
• Azelex Dosage
• Azelex Use in Pregnancy & Breastfeeding
• Azelex Drug Interactions
• Azelex Support Group
• 2 Reviews for Azelex - Add your own review/rating

Compare Azelex with other medications

• Acne
• Rosacea