Class: Anticholinergic Agents
VA Class: AU350
CAS Number: 52-49-3
Introduction
Antimuscarinic antiparkinsonian agent.a b
Uses for Trihexyphenidyl Hydrochloride
Parkinsonian Syndrome
Adjunctive treatment of all forms of parkinsonian syndrome.a b
May reduce the frequency and duration of oculogyric crises, salivation, spastic contractions, and dyskinesia, and relieve mental inertia and depression characteristic of all forms of parkinsonian syndrome.b
Drug-Induced Extrapyramidal Reactions
Control of extrapyramidal reactions induced by antipsychotic agents (e.g., phenothiazines, thioxanthenes).a b
Trihexyphenidyl Hydrochloride Dosage and Administration
Administration
Oral Administration
Administer orally before or after meals, depending on patient reaction.a b Administer before meals in patients with excessive xerostomia.a Administer after meals if nausea occurs.a
May be administered 3 times daily; if a fourth dose is required, administer at bedtime.b
Mint candies, chewing gum, water, or administration of a saliva substitute (e.g., Xero-lube) may relieve xerostomia that may accompany administration after meals.a b
Dosage
Available as trihexyphenidyl hydrochloride; dosage expressed in terms of the salt.a
Adjust dosage carefully according to individual requirements and response.b
Adults
Parkinsonian Syndrome
Oral
Initially, 1 mg on first day.a Dosages may be increased in 2-mg increments at 3- to 5-day intervals up to a maximum of 6–10 mg daily.a b
Postencephalitic patients: 12–15 mg daily may be required.a b
When trihexylphenidyl is used as an adjunct to levodopa, consider reducing levodopa and trihexyphenidyl dosages.a Generally, 3–6 mg daily of trihexyphenidyl hydrochloride is adequate.a
If trihexyphenidyl is replacing another antiparkisonian agent, increase trihexyphenidyl dose as needed while decreasing other drug dose until complete replacement is achieved.b
Drug-Induced Extrapyramidal Reactions
Oral
Usual dosage: 5–15 mg total daily dosage.a b
Initially, 1 mg; if extrapyramidal reactions are not controlled within a few hours, progressively increase dosage until control is achieved. a b
Alternatively, to achieve a more rapid control, reduce dosage of the drug causing the reaction, then adjust the dosage of both drugs to attain the desired drug effect without extrapyramidal symptoms.b Once control of extrapyramidal reactions has been maintained for several days, dosage of trihexyphenidyl may be reduced or discontinued.b
Prescribing Limits
Adults
Parkinsonian Syndrome
Oral
Maximum of 6–10 mg daily in most patients; postencephalitic patients may require 12–15 mg daily.a b
Special Populations
Hepatic Impairment
No specific dosage recommendations at this time.a
Renal Impairment
No specific dosage recommendations at this time.a
Geriatric Patients
Patients ≥60 years of age: Initiate with low dosage; titrate dosage gradually.a
Cautions for Trihexyphenidyl Hydrochloride
Contraindications
Known hypersensitivity to trihexylphenidyl or any ingredient in the formulation.c
Warnings/Precautions
Warnings
Ophthalmic Effects
Possible increased ocular tension.a Possible precipitation of glaucoma in patients receiving prolonged therapy.a c
Use with caution in patients with glaucoma.a c
Periodic gonioscopic evaluation and intraocular pressure monitoring recommended.a b
General Precautions
Tardive Dyskinesia
Antiparkinsonian agents do not alleviate symptoms of tardive dyskinesia and may aggravate these symptoms.a
Cardiovascular Effects
Possible tachycardia;a use with caution and carefully monitor patients with cardiac disease or hypertension.a c
GU Effects
Possible urinary hesitancy and retention;a c use with caution and carefully monitor patients with prostatic hypertrophy or obstructive disease of the GU tract.a c
CNS Effects
Possible mental confusion, disorientation, agitation, hallucinations, and psychotic-like symptoms.a
GI Effects
Possible decreased intestinal mobility and paralytic ileus; use with caution in patients with obstructive diseases of the GI tract.a
Specific Populations
Pregnancy
Category C.d
Geriatric Use
Possibility exists of greater sensitivity to the drug in some geriatric individuals.a
Hepatic Impairment
Use with caution; careful monitoring recommended.a
Renal Impairment
Use with caution; careful monitoring recommended.a
Common Adverse Effects
Dry mouth, blurred vision, dizziness, nausea, nervousness.a
Interactions for Trihexyphenidyl Hydrochloride
Specific Drugs
Drug | Interaction | |
|---|---|---|
Anticholinergic agents | Increased risk of adverse anticholinergic effectsc |
Trihexyphenidyl Hydrochloride Pharmacokinetics
Absorption
Rapidly absorbed from the GI tract following oral administration.b
Onset
Following oral adminstration, onset of action occurs within 1 hour.b
Duration
6–12 hours.b
Elimination
Elimination Route
Excreted principally in urine, probably as unchanged drug.b
Stability
Storage
Oral
Elixir
20–25°C.e Do not freeze.e
Tablets
20–25°C.a
ActionsActions
Exhibits atropine-like action and exerts antispasmodic effects on parasympathetic-innervated peripheral structures, including smooth muscle.a b
Exact mechanism of action in parkinsonian syndrome not understood; may result from blockade of efferent impulses and from central inhibition of cerebral motor centers.b
Competitively inhibits acetylcholine or other cholinergic stimuli at autonomic effectors innervated by postganglionic nerves.c
Exhibits weak mydriatic, antisialagogue, and cardiovagal blocking effects.b
Advice to Patients
Potential for drug to impair mental alertness or physical coordination; use caution when driving or operating machinery until effects on individual are known.a
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs and dietary or herbal supplements, as well as concomitant illnesses.a
Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.a
Importance of informing patients of other important precautionary information.a (See Cautions.)
Preparations
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
Oral | Elixir | 2 mg/5 mL* | Trihexyphenidyl Hydrochloride Elixir | Mikart, Pharmaceutical Associates, Pharmaceutical Ventures |
Tablets | 2 mg* | Trihexyphenidyl Hydrochloride Tablets | URL, Vintage, Watson, West-Ward | |
5 mg* | Trihexyphenidyl Hydrochloride Tablets | URL, Vintage, Watson, West-Ward |
Comparative Pricing
This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.
Trihexyphenidyl HCl 0.4MG/ML Elixir (PHARMACEUTICAL ASSOCIATES): 473/$30.99 or 1419/$79.97
Trihexyphenidyl HCl 2MG Tablets (WATSON LABS): 90/$22.99 or 180/$39.97
Trihexyphenidyl HCl 5MG Tablets (WEST-WARD): 180/$65.99 or 280/$95.97
Disclaimer
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions October 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
References
a. Watson Laboratories Inc. trihexyphenidyl hydrochloride tablets, USP. prescribing information. Corona, CA; 2005 May.
b. AHFS drug information 2006. McEvoy GK, ed. Trihexyphenidyl. Bethesda, MD: American Society of Health-System Pharmacists; 2006:1256.
c. AHFS drug information 2006. McEvoy GK, ed. Antimuscarinics/Antispasmodics General Statement. Bethesda, MD: American Society of Health-System Pharmacists; 2006:1257-64].
d. Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation, 7th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005:1628
e. Pharmaceutical Associates, Inc. Trihexyphenidyl HCl elixir prescribing information. Greenville, SC; 2002 May.
More Trihexyphenidyl Hydrochloride resources
- Trihexyphenidyl Hydrochloride Side Effects (in more detail)
- Trihexyphenidyl Hydrochloride Use in Pregnancy & Breastfeeding
- Drug Images
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- Trihexyphenidyl Hydrochloride Support Group
- 4 Reviews for Trihexyphenidyl Hydrochloride - Add your own review/rating
- Trihexyphenidyl MedFacts Consumer Leaflet (Wolters Kluwer)
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